Author/Editor		Weis, S; Llenos, IC; Buettner, A; Rehban, A; Soreth, D; Mehraein, P
Title		Macroscopic morphometry of the human brain in neurodegeneration
Type		članek
Source		Acta Stereol
Vol. and No.		Letnik 12, št. 2
Publication year		1993
Volume		str. 299-304
Language		eng
Abstract		Human brains were analysed, by means of stereology, at the microscopic level, for the following reasons: (1) to compare Alzheimer's disease (AD) and Parkinson's disease (PD) and to determine the presence of AD changes in PD, and vice-versa, (2) to detect signs of atrophy in the brains of HIV-1 infected patients, and (3) to provide baseline quantitative data for further morphometric analyses using MR-imaging. The volumes of 20 cortical and 17 subcortical brain structures were estimated using Cavalieri's principle. Furthermore, the surface area and the mean coritcal thickness of all cortical structures were measured. In ALzheimer's disease, the volume of the ippocampus, the parahippocampal gyrus, the basal and medial aspects of the frontal lobe, the insula, the cingulate gyrus as well as the frontal and parieto-occipital white matter were significantly reduced. No changes were seen in subcortical brain structures. In Parkinson's disease, no significant reductions in volume were found. No significant changes were found in the cerebral cortex of HIV-1 infected patients as compared to age- and sex-metched controls, Only a significant reduction in wolume was found in the internal capsule. The lack of significant changes in HIV-1 ingrvzrf brains might be attributed to the selection of the sample which was composed of brains with the neuropathological diagnosis of HIV-1 encephalitis but showing no remarkable grossanatomical changes.
Descriptors		ALZHEIMER'S DISEASE PARKINSON DISEASE HIV INFECTIONS HISTOLOGICAL TECHNIQUES AGE FACTORS SEX FACTORS NUCLEAR MAGNETIC RESONANCE