Author/Editor		Schernthaner, Guntram; Drexel, Heinz; Moshkovich, Evgeny; Zilaitiene, Birute; Martinka, Emil; Czupryniak, Leszek; Várkonyi, Tamás; Janež, Andrej; Ducena, Kristine; Lalić, Katarina
Title		SGLT2 inhibitors in T2D and associated comorbidities - differentiating within the class
Type		članek
Vol. and No.		, št. Vol. 19
Publication year		2019
Volume		str. 1-13
ISSN		1472-6823 - BMC endocrine disorders
Language		eng
Abstract		Background For patients with type 2 diabetes (T2D), cardiovascular disease (CVD) is the single most common cause of mortality. In 2008 and 2012, the Federal Drug Administration (FDA) and the European Medicines Agency (EMA) respectively mandated cardiovascular outcomes trials (CVOTs) on all new anti-diabetic agents, as prospective trials statistically powered to rule out excess cardiovascular risk in patients with T2D. Unexpectedly, some of these CVOTs have demonstrated not only cardiovascular safety, but also cardioprotective effects, as was first shown for the SGLT2 inhibitor empagliflozin in EMPA-REG OUTCOME. Expert opinion To debate newly available CVOT data and to put them into context, we convened as a group of medical experts from the Central and Eastern European Region. Here we describe our discussions, focusing on the conclusions we can draw from EMPA-REG OUTCOME and other SGLT2 inhibitor CVOTs, including when considered alongside real-world evidence. Conclusion CVOTs investigating SGLT2 inhibitors have suggested benefits beyond glucose lowering that have been confirmed in real-world evidence studies.
Keywords		type 2 diabetes SGLT2 inhibitor cardiovascular disease sladkorna bolezen tipa 2 SGLT2 inhibitor bolezni srca in ožilja