Author/Editor		Tepeš, Bojan
Title		Need for primary and secondary gastric cancer prevention in Central and Eastern Europe
Type		članek
Vol. and No.		Letnik 3, št. 4
Publication year		2017
Volume		str. 182-187
ISSN		2415-9107
Language		eng
Abstract		Gastric cancer (GC) is the fifth most common malignancy in the world, with almost 1 million new cases annually. The highest incidence of gastric cancer is in East Asia, with Central and East Europe second. Average five-year survival is around 22% worldwide, but it can be as high as 90% if GC is found in an early stage. Helicobacter pylori (H. pylori) is a group I carcinogen and can cause GC in 2.9% of those infected. According to the International Agency for Research on cancer (IARC), 89% of all GCs are caused by H. pylori infection. Factors which influence the outcome of infection include: H. pylori strain, host immune reaction to infection, use of salt, smoking, gastric polyps, genetic mutations (CDH1) and coinfection with Epstein-Barr virus.
Keywords		gastric cancer Helicobacter pylori preneoplastic changes primary prevention secondary prevention