Author/Editor		Zimet, Zlatko; Bilban, Marjan; Osredkar, Joško; Poljšak, Borut; Fabjan, Teja; Kumer, Kristina
Title		Three day environmental exposure may trigger oxidative stress development and provoke adaptive response resulting in altered antioxidant activity
Type		članek
Vol. and No.		Letnik 48, št. 7
Publication year		2019
Volume		str. 1284-1291
ISSN		2251-6085 - Iranian journal of public health
Language		eng
Abstract		We aimed to investigate the polluted working environment triggers oxidative stress and alter enzymatic antioxidant activity by a short-term interval. Methods: The experimental study, performed in 2014, involved 94 workers from the Velenje Coalmine in Slovenia, arranged into three groups according to a number of consecutive working days in a mineshaft, supported by a control group. Levels of the antioxidant enzymes (GPx, CAT, SOD) together with TAC (the combined effect of all antioxidants) and 8-isoprostane (a biological marker of oxidative stress/damage) were measured in human plasma. Results: Workers occupationally exposed for three consecutive working days had significantly increased 8-isoprostane biomarker, a parameter of oxidative stress (P<0.001). The antioxidant levels of TAC (P<0.001), CAT (P<0.001) and SOD (P<0.001) were all significantly decreased compared to a control group. Conclusion: Workers in polluted working environment had significantly increased oxidative stress and altered antioxidant activity already on a third consecutive working day.
Descriptors		Oksidativni stres Okolje
Keywords		polluted working environment oxidative stress 8-isoprostane enzymatic antioxidant activity