| Author/Editor | Nosan, Gregor; Paro Panjan, Darja; Ihan, Alojz; Kopitar, Andreja Nataša; Čučnik, Saša; Avčin, Tadej | |
| Title | Vaccine immune response, autoimmunity and morbidity after neonatal blood exchange transfusion | |
| Type | članek | |
| Vol. and No. | Letnik 37, št. 30 | |
| Publication year | 2019 | |
| Volume | str. 4076-4080 | |
| ISSN | 0264-410X - Vaccine | |
| Language | eng | |
| Abstract | Introduction A blood exchange transfusion (BET) is most commonly performed to treat severe neonatal haemolytic disease. A distinct form of blood transfusion adverse reaction is transfusion-related immunomodulation. The purpose of our retrospective single-centre case-control cohort study was to investigate whether a blood exchange transfusion in the neonatal period provokes immunomodulation and affects humoral immune response to vaccination, morbidity and occurrence of autoantibodies. Methods Study subjects were 74 apparently healthy children, who were born at term as appropriate for gestational age and received four doses of diphtheria and tetanus toxoid vaccine. Forty-one received BET due to neonatal hemolytic disease and no other blood product afterwards, while 33 did not receive any blood products. Analysis of diphtheria, tetanus and autoimmune antibodies was performed and their medical records were analyzed for infectious, allergic, cancerous and autoimmune diseases. Results A clearly exaggerated immune response to diphtheria (1.016 IU/mL, 95% confidence interval (CI) 0.662-1.369 IU/mL vs. 0.515 IU/mL, 95% CI 0.363 to 0.626 IU/mL, P=0.011) and slightly exaggerated immune response to tetanus vaccine (1.798 IU/mL, 95% CI 1.180-2.416 IU/mL vs. 1.036 IU/mL, 95% CI 0.398-1.673 IU/mL, P=non-specific) were observed in BET subjects. A propensity towards autoimmunity (25.8% vs. 12.5%, P=non-specific) was observed in BET subjects. However, BET in the neonatal period did not influence the occurrence of bacterial, childhood viral diseases with exception of varicella (43.9% vs. 21.2%, P=0.040), autoimmune and cancer diseases. Conclusion BET impacted humoral immune response to diphtheria and tetanus vaccine and occurrence of autoimmune antibodies, but did not affect morbidity and the occurrence of autoimmune diseases. These effects could be related to massive antigenic load of BET and an accelerated priming of immune cells and consequent immunomodulation. | |
| Keywords | cepljenje cepivo proti difteriji-tetanusu imunomodulacija novorojenček vaccination diphtheria-tetanus vaccine immunomodulation newborn |