Author/Editor		Salvany-Celades, Maria; Zwan, Anita van der; Benner, Marilen; Šetrajčič Dragoš, Vita; Bougleux Gomes, Hannah Ananda; Iyer, Vidya; Norwitz, Errol R.; Strominger, Jack L.; Tilburgs, Tamara
Title		Three types of functional regulatory T cells control T cell responses at the human maternal-fetal interface
Type		članek
Vol. and No.		Letnik 27, št. 9
Publication year		2019
Volume		str. 2537-2547
ISSN		2211-1247 - Cell reports
Language		eng
Abstract		During pregnancy, maternal regulatory T cells (Tregs) are important in establishing immune tolerance to invading fetal extravillous trophoblasts (EVTs). CD25HIFOXP3+ Tregs are found at high levels in decidual tissues and have been shown to suppress fetus-specific and nonspecific responses. However, limited data are available on additional decidual Treg types and the mechanisms by which they are induced. This study investigated three distinct decidual CD4+ Treg types in healthy pregnancies with a regulatory phenotype and the ability to suppress T cell responses: CD25HIFOXP3+, PD1HIIL-10+, and TIGIT+FOXP3dim. Moreover, co-culture of HLA-G+ EVTs or decidual macrophages with blood CD4+ T cells directly increased the proportions of CD25HIFOXP3+ Tregs compared to T cells cultured alone. EVTs also increased PD1HI Tregs that could be inhibited by HLA-C and CD3 antibodies, suggesting an antigen-specific induction. The presence of distinct Treg types may allow for the modulation of a variety of inflammatory responses in the placenta.
Keywords		T celice imunska toleranca nosečnost molekularna diagnostika T cells immune tolerance pregnancy molecular diagnostics