Author/Editor		Roviš, Darko; Vasiljev Marchesi, Vanja; Jenko Pražnikar, Zala; Petelin, Ana; Drevenšek, Gorazd; Peruč, Dolores; Černelič Bizjak, Maša
Title		Mental health and drug use severity
Type		članek
Publication year		2019
Volume		str. str.
ISSN		0963-8237 - Journal of mental health (Abingdon, England)
Language		eng
Abstract		Background: Many risk factors lead to opioid use and drug-related problems. One of the challenges to understand behavioural factors, drug problems and psychopathology is to identify biological markers that are suitable for research on broad substance abuse and dependence involving human participants. Aims: The study has examined the relationships between the self-reported childhood history of trauma, parental bonding, psychopathology, impulsivity, current resiliency, two neuropeptides, possible markers of behaviour and emotion regulation, and severity of drug-related problems. Methods: One hundred and sixty-seven individuals with a history of opioid use completed questionnaires. Serum neuropeptide Y (NPY) and substance P (SP) levels were analysed. Moderating and mediating relationships between variables were examined using structural equation modelling (SEM). Results: Antisocial features, depression, impulsivity, SP, NPY, emotional neglect and resilience are associated with severity of drug-related problems. SP is associated with antisocial personality traits. Conclusions: The novelty of this study is the proposed possible link between biochemical markers, antisocial features and behavioural and emotional regulation. Serum NPY and SP levels have a potential to be used as a biomarker in opioid users before and in the treatment process to account for interactions between biological vulnerabilities and childhood risk factors in predicting behavioural adjustment and more severe drug-related problems.
Keywords		psychopathology drug use comorbidity psihopatologija uporaba drog komorbidnost