Author/Editor		Verkhratsky, Alexei; Parpura, Vladimir; Vardjan, Nina; Zorec, Robert
Title		Physiology of astroglia
Type		članek
Source		In: Neuroglia in neurodegenerative diseases Singapore : Springer
Publication year		2019
Volume		str. 45-91
ISSN		2214-8019 - Advances in experimental medicine and biology
Language		eng
Abstract		Astrocytes are principal cells responsible formaintaining the brain homeostasis. Additionally, these glial cells are also involved in homocellular (astrocyteastrocyte) and heterocellular (astrocyte-other cell types) signalling and metabolism. These astroglial functions require an expression of the assortment of molecules, be that transporters or pumps, to maintain ion concentration gradients across the plasmalemma and the membrane of the endoplasmic reticulum. Astrocytes sense and balance their neurochemical environment via variety of transmitter receptors and transporters. As they are electrically non-excitable, astrocytes display intracellular calcium and sodium fluctuations, which are not only used for operative signalling but can also affect metabolism. In this chapter we discuss the molecules that achieve ionic gradients and underlie astrocyte signalling.
Keywords		astrociti homoesostaza možganov nevrotransmiterski receptorji astrocytes brain homoesostasis neurotransmitter receptors