Author/Editor		Urh, Kristian; Žlajpah, Margareta; Boštjančič, Emanuela; Zidar, Nina
Title		Involvement of sulfatase 1 (SULF1) in colorectal cancer
Type		članek
Source		In: Proceedings Ljubljana : Genetic Society Slovenia
Publication year		2019
Volume		str. 19-24
Language		eng
Abstract		Colorectal cancer (CRC) is one of the most common cancers worldwide. Molecular pathways involved in CRC development include stepwise accumulation of mutations, epigenetic changes, and changes in gene expression, leading to uncontrolled cell division and an invasive phenotype. However, not all cases possess these changes suggesting that there should be undiscovered mechanisms for CRC development. We therefore investigated SULF1, previously identified as a CRC candidate gene using bioinformatics analysis. We included 65 biopsy samples from patients with adenoma, malignant adenoma, and CRC with and without nodal metastases. We examined expression of SULF1 using quantitative real-time polymerase chain reaction. Its expression progressively increased from adenoma, where it was down-regulated, to invasive CRC, where it was up-regulated. Our findings indicate an involvement of SULF1 in CRC carcinogenesis and progression.
Keywords		rak debelega črevesa in danke SULF1 diferenčno izražanje colorectal cancer SULF1 differential expression