Author/Editor		Goličnik, Marko
Title		Quantitative analysis of ultrasensitive responses with logarithmic mean difference
Type		članek
Vol. and No.		Letnik 83, št. 2
Publication year		2019
Volume		str. [1-10]
ISSN		0340-6253 - MATCH Communications in Mathematical and in Computer Chemistry
Language		eng
Abstract		Sigmoidal responses have been observed in various fields of biochemistry such as multisubunit protein chemistry, enzymology and signal transduction for decades. The input-output curves in these biological phenomena are often well-characterized by the Hill equation, and Koshland and Goldbeter defined them as ultrasensitive when an increase from 10% to 90% maximal activity occurs over less than an 81-fold change in input quantity; i.e. when the effective Hill coefficient related to the EC90/EC10 ratio as n = ln(81)/ln(EC90/EC10) is greater than 1. Contradictorily, by this definition of ultrasensitivity, a non-sigmoidal linear response curve is also ultrasensitive with n = 2. Therefore, I present in this report that the logaritmic mean of the EC90 and EC10 is more suitable for quantitative analysis of ultrasensitive phenomena.
Keywords		biokemija preobčutljivi odzivi kvantitativna analiza biochemistry ultrasensitive responses quantitative analysis