Author/Editor		Kojc, Nika; Večerić-Haler, Željka
Title		Antibody mediated rejection in kidney transplant recipients
Type		članek
Source		In: Perioperative care for organ transplant recipient London : IntechOpen
Publication year		2019
Volume		str. 67-92
Language		eng
Abstract		Antibody mediated rejection (ABMR) presents a significant challenge for long term graft survival in kidney transplantation. New technologies, including genomic studies and assays to detect and define donor-specific antibodies, have provided important insights into the pathophysiology and diagnosis of ABMR. Unfortunately, this progress has not yet translated into better outcomes for patients, as in the absence of a drug able to suppress antibody generation by plasma cells, available therapies can only slow down graft destruction. This chapter reviews the current understanding of ABMR, and details its diagnosis, and treatments, both those established in current routine clinical practice and those on the horizon.
Keywords		kidney transplantation antibody mediated rejection humoral rejection presaditev ledvic zavračanje s protitelesi humoralna zavrnitev