Author/Editor		Saba, Nabil F.; Chen, Zhuo Gerogia; Haigentz, Missak; Bossi, Paolo; Rinaldo, Alessandra; Rodrigo, Juan Pablo; Mäkitie, Antti A.; Takes, Robert P.; Strojan, Primož; Vermorken, Jan B.; Ferlito, Alfio
Title		Targeting the EGFR and immune pathways in squamous cell carcinoma of the head and neck (SCCHN)
Type		članek
Vol. and No.		Letnik 18, št. 11
Publication year		2019
Volume		str. str. 1909-1915
ISSN		1535-7163 - Molecular cancer therapeutics
Language		eng
Abstract		Despite the recent approval of immune-modulatory agents, EGFR inhibition continues to be a cornerstone in the management of squamous cell carcinoma of the head and neck (SCCHN) namely in combination with radiotherapy in the treatment of locoregionally advanced disease as well as in platinum-sensitive recurrent or metastatic disease in the first-line setting. Importantly, recent evidence has emerged supporting also an immune-modulatory effect of EGFR inhibition, and interest has now focused on utilizing these effects in the current treatment approaches for SCCHN. In this report, we review the rationale and evidence supporting the forging of this new alliance in optimizing the treatment of SCCHN.
Keywords		ploščatocelični rak rak glave in vratu radioterapija squamous cell carcinoma head and neck cancer radiotherapy