Author/Editor		Jeruc, Jera; Čugura, Tanja; Tomažič, Aleš; Boštjančič, Emanuela
Title		MDM2-positive papillary sarcomatoid renal cell carcinoma
Type		članek
Publication year		2019
Volume		str. str.
ISSN		0945-6317 - Virchows Archiv : an international journal of pathology
Language		eng
Abstract		Sarcomatoid renal cell carcinoma is a highly aggressive form of carcinoma, histologically showing both carcinomatous and mesenchymal component in different proportions. We present a case of advanced type 1 papillary sarcomatoid renal cellcarcinoma infiltrating adjacent organs and showing positivity for MDM2 by immunohistochemistry and MDM2 amplification by fluorescence in situ hybridization. This finding, together with sarcomatoid morphology, poses a potential pitfall for diagnosis with dedifferentiated liposarcoma. MDM2 is known to be altered in various human sarcomas. Only recently, MDM2 alterations have been reported in carcinomas. The presented case illustrates the need of thorough sampling with clinic-pathological corre-lation before making a final diagnosis in sarcomatoid retroperitoneal tumours. Additionally, the potential clinical implications of MDM2 amplification in renal cell carcinoma are discussed.
Keywords		biopsije materničnega vratu displazija materničnega vratu genotipizacija HPV cervical tissue biopsies cervical dysplasia HPV genotyping