| Author/Editor | Dingemans, Anne-Marie C.; Hendriks, Lizza E. L.; Berghmans, Thierry; Levy, Antonin; Hasan, Baktiar; Faivre-Finn, Corinne; Giaj-Levra, Matteo; Giaj-Levra, Niccolò; Girard, Nicolas; Greillier, Laurent; Čufer, Tanja | |
| Title | Definition of synchronous oligometastatic non-small cell lung cancer | |
| Type | članek | |
| Vol. and No. | Letnik 14, št. 12 | |
| Publication year | 2019 | |
| Volume | str. str. 2109-2119 | |
| ISSN | 1556-1380 - Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer | |
| Language | eng | |
| Abstract | Introduction. Improved outcome has been shown in patients with synchronous oligometastatic (sOM) NSCLC when treated with radical intent. As a uniform definition of sOM NSCLC is lacking, we developed a definition and diagnostic criteria by a consensus process. Methods. A pan-European multidisciplinary consensus group was established. Consensus questions were built on the basis of current controversies, and definitions were extracted from a survey, cases and a systematic review. This statement was formulated during a consensus meeting. Results. It was determined that definition of sOM NSCLC is relevant when a radical treatment that may modify the disease course (leading to long-term disease control) is technically feasible for all tumor sites with acceptable toxicity. On the basis of the review, a maximum of five metastases and three organs was proposed. Mediastinal lymph node involvement was not counted as a metastatic site. Fludeoxyglucose F 18 positron emission tomography-computed tomography and brain imaging were considered mandatory. A dedicated liver magnetic resonance imaging scan was advised for a solitary liver metastasis, and thoracoscopy and biopsies of distant ipsilateral pleural sites were recommended for a solitary pleural metastasis. For mediastinal staging, fludeoxyglucose F 18 positron emission tomography-computed tomography was deemed the minimum requirement, with pathological confirmation recommended if this influences the treatment strategy. Biopsy of a solitary metastatic location was mandated unless the multidisciplinary team is of the opinion that the risks outweigh the benefits. Conclusion. A multidisciplinary consensus statement on the definition and staging of sOM NSCLC has been formulated. This statement will help to standardize inclusion criteria in future clinical trials. | |
| Descriptors | Carcinoma, non-small cell lung Neoplasm staging Nedrobnocelični karcinom pljuč Stadij novotvorb | |
| Keywords | nedrobnocelični rak pljuč oligometastatska bolezen poročilo non-small cell lung cancer oligometastatic disease report |