Author/Editor		Cho, Nicole A.; Klančič, Teja; Nettleton, Jodi E.; Paul, Heather A.; Reimer, Raylene A.
Title		Impact of food ingredients (Aspartame, Stevia, Prebiotic Oligofructose) on fertility and reproductive outcomes in obese rats
Type		članek
Vol. and No.		Letnik 26, št. 11
Publication year		2018
Volume		str. 1692-1695
ISSN		1930-7381 - Obesity (Silver Spring, Md.)
Language		eng
Abstract		Objective: This study aimed to investigate the interaction between obesity, low-calorie sweeteners, and prebiotic oligofructose on reproductive parameters in rats.Methods: Data were derived from two separate studies of female Sprague-Dawley rats with (1) Lean (n = 24), (2) Obese (n = 27), (3) Obese+Aspartame (n = 14), (4) Obese+Stevia (n = 15), and (5) Obese+Prebiotic (n = 15) groups. Obesity was induced with a high-fat/high-sucrose diet prior to pregnancy. In one study, human-approved doses of aspartame (5-7 mg/kg/d) and stevia (2-3 mg/kg/d) in drinking water were examined, and in the second, 10% prebiotics (oligofructose) in the diet was examined. Reproductive parameters, including fertility, pregnancy, and delivery indexes, were analyzed.Results: Obesity significantly reduced pregnancy index in Obese dams (60.7% successful pregnancies) compared with lean (100%). Obesity also reduced the number of pups born alive and pup survival percent-age compared with those of Lean dams (P < 0.001). Only 53.3% of rats were able to conceive in the Obese+Stevia group, but if rats did become pregnant, they had 100% pregnancy and delivery index. While prebiotic administration rescued the pregnancy index, it could not remediate pup survival percentage (P = 0.025) in Obese dams.Conclusions: Both obesity status and dietary ingredients affect the ability to conceive. Future rigorously controlled studies designed to examine reproductive outcomes in depth are needed to confirm these findings.
Keywords		sestavina hrane vpliv na plodnost reproduktivni rezultati food ingredients impact on fertility reproductive outcomes