| Author/Editor | Hočevar, Alojzija; Tomšič, Matija; Jurčić, Vesna; Perdan-Pirkmajer, Katja; Rotar, Žiga | |
| Title | Predicting gastrointestinal and renal involvement in adult IgA vasculitis | |
| Type | članek | |
| Vol. and No. | Letnik 21, št. 1 | |
| Publication year | 2019 | |
| Volume | str. 1-7 | |
| ISSN | 1478-6362 - Arthritis research & therapy | |
| Language | eng | |
| Abstract | Background:Immunoglobulin A vasculitis (IgAV) is still poorly defined in the adult population. We aimed todetermine the predictors of gastrointestinal (GI) or renal involvement in adult IgAV.Methods:The prospective study included histologically proven adult IgAV cases diagnosed between January 2013and July 2019 at our secondary/tertiary rheumatology center. We evaluated the role of clinical and the laboratoryparameters as markers predicting the GI or renal involvement in IgAV, using the multiple logistic regression analysis.Results:During the 79-month observation period, we identified 214 new adult IgAV cases (59.3% males, median(interquartile range) age 64.6 (57.2-76.7) years). The GI tract and renal involvement developed in 58 (27.1%) and 83(38.8%) cases, respectively (concurrently in 26 (12.1%) cases). In the multivariate logistic regression analysis, generalizedpurpura (OR 6.74 (95%CI 3.18-14.31)), the pre-treatment neutrophil to lymphocyte ratio (NLR) > 3.5 (OR 2.78 (95%CI1.34-5.75)), and elevated serum IgA levels (OR 0.40 (95%CI 0.20-0.79)) were extracted as factors associated with GIcomplications, whereas current smoking (OR 3.23 (95%CI 1.50-6.98)), generalized purpura (OR 1.98 (95%CI 1.08-3.61)),elevated serum IgA (OR 2.25 (95%CI 1.21-4.18)), NLR > 3.5 (OR 1.96 (95%CI 1.02-3.77)), and marginally age (1.02 (95%CI1.01-1.04)) emerged as factors associated with renal complications.Conclusion:Generalized purpura and pre-treatment NLR predicted both GI and renal involvement, whereas activesmoking was associated with renal involvement, and the serum IgA level had a divergent effect on renal and GIinvolvement in adult IgAV. | |
| Keywords | IgA vasculitis gastrointestinal involvement renal involvement IgA vaskulitis prizadetost prebavil prizadetost ledvic |