| Author/Editor | Janež, Jurij | |
| Title | Early recognition of anastomotic leak and septic complications in patients after colorectal resections | |
| Type | članek | |
| Vol. and No. | Letnik 2, št. 1 | |
| Publication year | 2020 | |
| Volume | str. 51-53 | |
| ISSN | 2591-2275 | |
| Language | eng | |
| Abstract | Backgrounds. Colorectal cancer is the third most common ma-lignancy in the world. Improvement in surgical techniques and adjuvant treatment with chemotherapy and radiation have im-proved overall survival. The mainstay of treatment is still sur-gery with radical tumor resection and adequate lymphadenec-tomy. The most serious surgical complication after surgery is anastomotic leakage and septic complications, which often require another surgery and stoma formation, and increase mortality, morbidity, total hospital stay, and overall costs. This prospective clinical study will evaluate some biomarkers as possible markers of early anastomotic leakage recognition and earlier intervention.Methods. A prospective non-randomized longitudinal clinical study in patients undergoing curative resection due to colorec-tal cancer will be performed. The study will include approx-imately 100 patients in a 3-year period. Preoperative blood samples will be taken to determine the inflammatory markers (leukocytes, C-reactive protein, procalcitonin, interleukin-6, interleukin-10, tumor-necrosis factor alpha, lactate, and car-cinoembryonic antigen). All these markers will be determined from blood samples and from abdominal drain fluid 6 to 8 hours after surgery and then from the 1st to 5th day after surgery.Discussion. The aim of this study is to elucidate the role of in-flammatory biomarkers, lactate, and carcinoembryonic antigen as possible biomarkers for early recognition and prompt treat-ment of patients with anastomotic leakage after colorectal re-sections. Many studies have also been published on this topic, and we believe that our study will provide new and valuable in-formation about this important topic. | |
| Keywords | colorectal cancer surgery resection kolorektalni rak operacija resekcija |