| Author/Editor | Rus, Tomaž; Jamšek, Jan; Berlot, Rok; Šurlan Popović, Katarina; Grmek, Marko; Trošt, Maja | |
| Title | Nuklearnomedicinske preiskave pri diagnosticiranju demence in parkinsonizmov | |
| Translated title | Nuclear medicine investigations in dementia and parkinsonism | |
| Type | članek | |
| Vol. and No. | Letnik 89, št. 3/4 | |
| Publication year | 2020 | |
| Volume | str. 203-222 | |
| ISSN | 1318-0347 - Zdravniški vestnik : glasilo Slovenskega zdravniškega društva : Slovenian medical journal | |
| Language | slv | |
| Abstract | The incidence of neurodegenerative brain disorders presenting as dementia or parkinsonism is increasing with aging population. Early and correct diagnosis is essential for the exclusion of potentially curable causes, to optimize symptomatic treatment, social care and to select patients for clinical trials. Final diagnosis of most neurodegenerative brain diseases can only be made at pathohistological examination of the brain tissue. However, functional nuclear-medicine investigations contribute greatly to the diagnosis in vivo. Changes in regional brain metabolism, neurotransmitter system dysfunction and misfolded protein deposition can be observed. Based on specific changes in regional brain metabolism measured with 18F-FDG PET we can distinguish between Alzheimer's disease, dementia with Lewy body and frontotemporal dementia and between Parkinson's disease and other neurodegenerative parkinsonisms. Dopaminergic system imaging (e.g. dopamine transporter scintigraphy, DaTSCAN) enables us to discriminate neurodegenerative parkinsonism from alternative causes. Excessive deposition of amyloid-[beta], a pathological hallmark of Alzheime's disease, can be identified with amyloid PET already in preclinical subjects. Nuclear medicine imaging methods, indications, characteristic findings and limitations of these investigations in neurodegenerative brain disorders are presented in this article. | |
| Keywords | metabolizem možganov scintigrafija dopaminskega prenašalca nevrodegenerativne bolezni brain metabolism dopamine transporter scintigraphy neurodegenerative disorders |