Author/Editor		Ihan, Alojz; Grosek, Štefan; Štubljar, David
Title		An in vitro evaluation of the red cell damage and hemocompatibility of different central venous catheters
Type		članek
Vol. and No.		, št. Vol. 2020
Publication year		2020
Volume		str. 1-9
ISSN		2314-6141 - BioMed research international
Language		eng
Abstract		Background. The aim of our study was to evaluate the damaging impact of characteristics of the central venous catheters (CVCs) onred blood cells.Methods. CVCs from three different manufacturers were analyzed, including the presence of coating, tunnelgeometry, length, lumen diameter, and number of lumens with two respectiveflow rates (33 mL/min and 500 mL/min). Bloodcell damage was defined by analyzing microparticle (MP) and hematologic analysis. MPs were isolated by ultracentrifugation oferythrocyte concentrate and analyzed on aflow cytometer.Results. Characteristics of catheters were not associated with bloodcell damage at a lowflow rate but showed an effect with a highflow rate. CVCs with a polyhexanide methacrylate coating havecaused statistically less blood cell damage than noncoated CVCs. The length of lumens, diameter, and geometry of the tunnelshowed no differences in blood cell damage. Meanwhile, the number of lumens was predicted to have a greater effect on theerythrocyte damage, which was revealed with the formation of MPs and hematological parameters. CVCs withfive lumenscaused significantly less damage to the blood cells than CVCs with a single lumen. Moreover, a highflow rate of 500 mL/mincaused less damage to the blood cells than a low rate of 33 mL/min.Conclusion. Properties of CVCs are an important factor forquality patient care, especially when transfusing blood with highflow rates, as we want to provide a patient with high-qualityblood with as few damaged cells as possible.
Keywords		central venous catheters red blood cells microparticles hematologic analysis centralni venski katetri rdeče krvne celice mikro delci hematološka analiza