Author/Editor		Witkin, Jeffrey M.; Golani, Lalit K.; Černe, Rok; Rahman, Md. Toufiqur; Li, Guanguan; Poe, Michael M.; Cook, James M.; Smith, Jodi L.
Title		Facilitation of social support through negative allosteric modulation of [alpha]5-associated GABA[sub]A receptors
Type		članek
Vol. and No.		Letnik 3, št. 3
Publication year		2019
Volume		str. 1-14
ISSN		2638-1311
Language		eng
Abstract		Major depressive disorder is a highly-prevalent and debilitating disorder in the aged population. Accumulating clinical evidence suggests a key role for social support in helping to mitigate depression. Preclinical data are reviewed that indicate that selective negative allosteric modulation of [alpha]5-containing GABAA receptors, as with RY-080, might rapidly impact depression in patients. Further, preclinical data in transgenic mice modeling neurodegenerative diseases has suggested that this mechanism might also function to reduce agitation and aggression. These data are discussed in terms of the concept of Facilitation of Social Support (FOSS). The concept posits that the expression of depression, agitation, and aggression, alone or in concert, reduces social support and thereby weakens this social link as a positive therapeutic intervention. Drugs like RY-080 or other interventions (psychotherapy) that dampen these behaviors will facilitate social support and further help to mitigate these behaviors. Thus, FOSS is proposed as a dual-acting mechanism with one component being drug or therapy-induced suppression of symptoms or disease, and the facilitation of social support that derives from this suppression as component number two. These processes are reciprocal, self-sustaining, and should be additive or synergistic.
Keywords		depression social support elderly depresija socialna podpora starejši