Author/Editor		Šuput, Jasna; Slana Ozimič, Anka; Vovk, Andrej; Šuput, Dušan; Repovš, Grega; Dovč, Klemen; Bratina, Nataša; Avbelj, Magdalena; Battelino, Tadej
Title		Acute hyperglycemia and spatial working memory in adolescents with type 1 diabetes
Type		članek
Publication year		2020
Volume		str. str.
ISSN		0149-5992 - Diabetes care
Language		eng
Abstract		Objective To investigate the effect of acute hyperglycemia on brain function in adolescents with type 1 diabetes (T1D). Research design and methods Twenty participants with T1D (aged 14.646 1.78 years) and 20 age-matched healthy control subjects (aged 14.4062.82 years) performed two functional MRI sessions. Participants with T1D performed the first scanning session under euglycemic and the second under hyperglycemic clamp (20 mmol/L [360 mg/dL]). Results Lower spatial working memory (sWM) capacity during acute hyperglycemia and significant differences in activation of regions of interest during different stages of the sWM task (P 5 0.014) were observed. Conclusions Acute hyperglycemia negatively affected sWM capacity in adolescents with T1D, which is relevant for daily functioning and academic performance
Keywords		acute hyperglycemia type 1 diabetes adolescents akutna hiperglikemija sladkorna bolezen tip 1 mladostniki