Author/Editor		Geršak, Ksenija; Geršak, Živa Miriam; Turčin, Arijana
Title		Reproductive aging
Type		članek
Source		In: Sex hormones in neurodegenerative processes and diseases London : IntechOpen
Publication year		2018
Volume		str. Str.[95]-125
Language		eng
Abstract		The female reproductive axis essentially comprises of the hypothalamic-pituitaryovarian axis and the mullerian-derived structures. The reproductive axis ages to a nonfunctional state (menopause) much earlier than the other organ systems do, at a time when a woman is otherwise healthy. The basis of reproductive senescence in women is oocyte depletion in the ovary. Perimenopause is deined by menstrual cycle and endocrine changes, such as disturbed ovarian-pituitary-hypothalamic feedback relationships, inaccurate estrogen levels, and decreased progesterone levels. Many psychopathological changes can take place, but most commonly women experience mild cognitive impairment, anxiety, irritability, mood swings, and depression. Estrogens inluence depression and depressive-like behavior through interactions with neurotropic factors and through an inluence on the serotonergic system.
Keywords		reproductive aging menopausal transition perimenopause reproduktivno staranje menopavzni prehod perimenopavza