Author/Editor		Zupančič, Daša; Hudoklin, Samo
Title		Raziskovalni modeli raka sečnega mehurja za izboljšanje diagnosticiranja in zdravljenja
Translated title		Research models of urinary bladder cancer for improved diagnostics and treatment
Type		članek
Vol. and No.		Letnik 89, št. 5/6
Publication year		2020
Volume		str. 301-319
ISSN		1318-0347 - Zdravniški vestnik : glasilo Slovenskega zdravniškega društva : Slovenian medical journal
Language		slv
Abstract		Urinary bladder cancer is one of the leading malignancies in men with high recurrence rate, thus representing a huge economic and social burden. Many different research models are used for studying potential improvements in the diagnostics and treatment of bladder cancer. In this re - view, the most widely used models are described, since they represent the approximation to the molecular and biological processes occurring during human bladder carcinogenesis. Processes at the cellular level are investigated by in vitro models of cell cultures, while processes occurring in whole organisms are explored in different animal models. The results obtained by these two approaches should also be evaluated on human biopsy samples before any new diagnostic pro - cedure or drug can be studied in clinical trials. We provide critical evaluation of advantages and disadvantages of specific models of the urinary bladder cancer and describe some of the studies using these models.
Keywords		sečni mehur rak raziskovalni modeli urinary bladder cancer research model