Author/Editor | Maraspin-Čarman, Vera; Lusa, Lara; Blejec, Tanja; Ružić-Sabljić, Eva; Pohar Perme, Maja; Strle, Franc | |
Title | Course and outcome of erythema migrans in pregnant women | |
Type | članek | |
Vol. and No. | Letnik 9, št. 8 | |
Publication year | 2020 | |
Volume | str. [1]-20 | |
ISSN | 2077-0383 - Journal of clinical medicine | |
Language | eng | |
Abstract | Information on Lyme borreliosis (LB) during pregnancy is limited. In the present study, the course and outcome of erythema migrans (EM) in 304 pregnant women, diagnosed in the period 1990-2015, was assessed and compared with that in age-matched non-pregnant women. The frequency of unfavorable outcome of pregnancies was also evaluated. The pregnant women reported constitutional symptoms less frequently than the non-pregnant women (22.4% vs. 37.2%, p < 0.001). Pregnant women diagnosed with EM later during pregnancy had a lower probability of reporting constitutional symptoms (odds ratio = 0.97 for 1-week difference in gestation week at diagnosis of EM, 95% CI: 0.94-0.99, p = 0.02). The outcome of pregnancy was unfavorable in 42/304 (13.8%) patients: preterm birth in 22/42 (52.4%), fetal/perinatal death in 10/42 (23.8%), and/or anomalies in 15/42 (35.7%). Several patients had potential explanation(s) for the unfavorable outcome. In conclusion, the course of early LB during pregnancy is milder than in age-matched non-pregnant women. The outcome of pregnancy with the treatment approach used in the present study (i.v. ceftriaxone 2 g once daily for 14 days) is favorable. | |
Keywords | erythema migrans Lyme borreliosis gestation eritema migrans Lymska borelioza gestacija |