Author/Editor		Odell, Edward; Gale, Nina; Thavaraj, Selvam; Nadal, Alfons; Zidar, Nina; Gnepp, Douglas R.
Title		Precursor lesions for squamous carcinoma in the upper aerodigestive tract
Type		članek
Source		In: Gnepp's diagnostic surgical pathology of the head and neck [Amsterdam] : Elsevier
Publication year		2021
Volume		str. 1-62
Language		eng
Abstract		The chapter provides historical context and biological understanding of precancerous changes, and describes disorders that predispose to squamous carcinoma. It discusses grading systems for use at different head and neck sites, with no single grading system being applicable to all, and those developed for cervix, colon, and other sites being inappropriate. Oral lesions are more diverse than laryngeal lesions, with a different approach required for dysplasia grading at the two sites because of the restricted opportunities for intervention in the larynx. The current World Health Organization classifications are included, together with newly described conditions such as human papillomavirus-associated dysplasia in the mouth. Terminology is updated and the normal microscopic anatomy of the sites reviewed.
Keywords		dysplasia grading erythroplakia larynx razvrščanje displazije eritroplakija larinks