Author/Editor		Gavrić, Aleksandar; Hanžel, Jurij; Žagar, Tina; Zadnik, Vesna; Plut, Samo; Štabuc, Borut
Title		Survival outcomes and rate of missed upper gastrointestinal cancers at routine endoscopy
Type		članek
Vol. and No.		Letnik 32, št. 10
Publication year		2020
Volume		str. 1312-1321
ISSN		0954-691X - European journal of gastroenterology & hepatology
Language		eng
Abstract		Data on the long-term survival outcome of patients with missed upper gastrointestinal cancers (MUGC) is lacking. Retrospective studies have found no difference in 1- and 2-year survival among patients with missed gastric and oesophageal cancers; we thus aimed to assess 3-year survival of patients with MUGC at oesophagogastroduodenoscopy. Methods This was a retrospective cohort study conducted at a single tertiary endoscopy centre. All oesophagogastroduodenoscopies performed between January 2007 and December 2015 were included in the study. The endoscopy database was cross-matched with the Slovenian Cancer Registry database. Missed cancers were defined as those diagnosed within 36months after a negative oesophagogastroduodenoscopy. Results During the study period, 29617 oesophagogastroduodenoscopies were performed. In total, 422 upper gastrointestinal cancers were diagnosed and the rate of missed gastric cancers was 7.3% (95% CI, 4.9%10.6%) (26/354), and 4.4% (95% CI, 0.9%12.4%) for oesophageal cancers (3/68). Three-year survival of patients with MUGC was shorter than that of those with non-MUGC, being 12% (95% CI, 1%25%) vs. 31% (95% CI, 26%36%) (P=0.043) for gastric and 0 vs. 9% (95% CI, 1%17%) (P=0.121) for oesophageal cancer. Conclusion Missed gastric cancer during oesophagogastroduodenoscopy may be associated with shorter 3-year survival compared to patients whose gastric cancer was diagnosed at index oesophagogastroduodenoscopy
Keywords		gastrointestinalni raki endoskopske preiskave register raka preživetje gastrointestinal cancers endoscopy cancer database endoscopy