Author/Editor		Borštnar, Špela; Večerić-Haler, Željka; Boštjančič, Emanuela; Pipan Tkalec, Živa; Kovač, Damjan; Lindič, Jelka; Kojc, Nika
Title		Uromodulin and microRNAs in kidney transplantation - association with kidney graft function
Type		članek
Vol. and No.		Letnik 21, št. 16
Publication year		2020
Volume		str. 1-11
ISSN		1422-0067 - International journal of molecular sciences
Language		eng
Abstract		Uromodulin and microRNAs (miRNAs) have recently been investigated as potential biomarkers for kidney graft associated pathology and outcome, with a special focus on biomarkers indicating specific disease processes and kidney graft survival. The study's aim was to determine whether expression of serum uromodulin concentration and selected miRNAs might be related to renal function in kidney transplant recipients (KTRs). The uromodulin concentration and expression of six selected miRNAs (miR-29c, miR-126, miR-146a, miR-150, miR-155, and miR-223) were determined in the serum of 100 KTRs with stable graft function and chronic kidney disease of all five stages. Kidney graft function was estimated with routine parameters (creatinine, urea, cystatin C, and Chronic Kidney Disease Epidemiology Collaboration study equations) and precisely measured using chromium-51 labelled ethylenediaminetetraacetic-acid clearance. The selected miRNAs were shown to be independent of kidney graft function, indicating their potential as biomarkers of associated kidney graft disease processes. In contrast, the serum uromodulin level depended entirely on kidney graft function and thus reflected functioning tubules rather than any specific kidney graft injury. However, decreased concentrations of serum uromodulin can be observed in the early course of tubulo interstitial injury, there by suggesting its useful role as an accurate, noninvasive biomarker of early (subclinical) kidney graft injury.
Keywords		mikroRNA uromodulin presaditev ledvic microRNA uromodulin kidney transplantation