Author/Editor		Redenšek, Sara; Dolžan, Vita
Title		The role of pharmacogenomics in personalization of the Parkinson's disease treatment
Type		članek
Publication year		2020
Volume		str. str.
ISSN		1462-2416 - Pharmacogenomics
Language		eng
Abstract		Parkinson's disease (PD) related phenotypes can vary among patients substantially, including response to dopaminergic treatment in terms of efficacy and occurrence of adverse events. Many pharmacogenetic studies have already been conducted to find genetic markers of response to dopaminergic treatment. Integration of genetic and clinical data has already resulted in construction of clinical pharmacogenetic models for prediction of adverse events. However, the results of pharmacogenetic studies are inconsistent. More comprehensive genome-wide approaches are needed to find genetic biomarkers of PD-related phenotypes to better explain the variability in response to treatment. These genetic markers should be integrated with clinical, environmental, imaging, and other omics data to build clinically useful algorithms for personalization of PD management.
Keywords		clinical algorithms clinical pharmacogenetic predictive models data integration klinični algoritmi klinični farmakogenetski napovedni modeli integracija podatkov