| Author/Editor | Kordiš, Špela; Vozel, Domen; Hribar, Manja; Božanić Urbančič, Nina; Battelino, Saba | |
| Title | The outcome of prompt concomitant single-dose high-concentration intratympanic and tapered low-dose oral systemic corticosteroid treatment for sudden deafness | |
| Type | članek | |
| Vol. and No. | Letnik 16, št. 2 | |
| Publication year | 2020 | |
| Volume | str. 201-206 | |
| ISSN | 1308-7649 - The Journal of International Advanced Otology | |
| Language | eng | |
| Abstract | Objectives: To investigate the efficacy of prompt concomitant corticosteroid treatment with single application of high-concentration intratympanic (IT) dexamethasone and tapered low-dose systemic methylprednisolone of an idiopathic sudden sensorineural hearing loss (ISSNHL). Materials and methods: Between September 2017 and September 2019, 86 adult patients met the criteria for the diagnosis of ISSNHL at baseline evaluation. The patients received immediate concomitant treatment with single high-concentration (24 mg/mL) IT dexamethasone and low-dose (48 mg) oral methylprednisolone for 1 week followed by tapered doses. Improvement in pure-tone average (PTA) and word recognition score (WRS) was determined after 1 and 6 months. Results: A total of 63 patients met the requirements for the analysis. PTA improved in 71% and WRS improved in 59% of patients with ISSNHL. PTA and WRS were statistically significantly different at different time points during the intervention (p<0.0005). Hearing improved in all measured frequencies from 125 to 8000 Hz until the second follow-up. In 65.4% of patients with tinnitus, the WRS has improved compared with 27.3% without tinnitus (p<0.05). In 69.2% of patients without vertigo, the WRS has improved compared with 41.7% with vertigo (p<0.05). Conclusion: Prompt concomitant single high-concentration IT and low-dose systemic corticosteroid treatment is efficient in recovering hearing loss and speech discrimination in ISSNHL. Tinnitus positively predicts hearing outcome. Vertigo negatively predicts speech discrimination recovery. | |
| Keywords | audiometry speech dexamethasone avdiometrija govor deksametazon |