Author/Editor		Ng, Wai Tong; Corry, June; Langendijk, Johannes A.; Lee, Anne W. M.; Mäkitie, Antti A.; Mendenhall, William M.; Rinaldo, Alessandra; Rodrigo, Juan Pablo; Saba, Nabil F.; Strojan, Primož
Title		Current management of stage IV nasopharyngeal carcinoma without distant metastasis
Type		članek
Vol. and No.		, št. Vol. 85
Publication year		2020
Volume		str. 1-10
ISSN		0305-7372 - Cancer treatment reviews
Language		eng
Abstract		Up to one in four patients with nasopharyngeal carcinoma present with non-metastatic stage IV disease (i.e. T4 or N3). Distinct failure patterns exist, despite the routine adoption of contemporary treatment modalities such as intensity modulated radiotherapy and systemic chemotherapy. Concurrent chemoradiotherapy (CCRT) followed by adjuvant chemotherapy or induction chemotherapy followed by CCRT are commonly employed in this setting, with the latter emerging as the preferred option. Additionally, emerging radiation technologies like proton therapy has become available offering new opportunities for prevention of radiation-induced side effects. This article reviews not only the current treatment strategies, but also discusses novel ways to tackle this challenging disease with respect to the patterns of failure.
Keywords		nazofarinks nazofaringealni rak radioterapija kemoterapija nasopharyngeal carcinoma radiotherapy chemotherapy