Author/Editor | Fokdal, Lars U.; Tanderup, Kari; Pötter, Richard; Sturdza, Alina; Kirchheiner, Kathrin; Chagari, Cyrus; Jürgenliemk-Schulz, Ina Maria; Šegedin, Barbara; Tan, Li-Tee; Hoskin, Peter J. | |
Title | Risk factors for ureteral stricture after radiochemotherapy including image guided adaptive brachytherapy in cervical cancer | |
Type | članek | |
Vol. and No. | Letnik 103, št. 4 | |
Publication year | 2019 | |
Volume | str. 887-894 | |
ISSN | 0360-3016 - International journal of radiation oncology, biology, physics | |
Language | eng | |
Abstract | Ureteral stricture is a rare but severe side effect of radiation therapy for locally advanced cervical cancer. This report describes the incidence and risk factors for ureteral stricture in a large patient cohort treated with 3-dimensional image guided adaptive brachytherapy and radiochemotherapy within the EMBRACE studies. Methods and materials: A total of 1860 patients were included. Treatment consisted of external beam radiation therapy (45-50 Gy in 25-30 fractions), concomitant cisplatin, and image guided adaptive brachytherapy. Grade 3 to 4 ureteral strictures were assessed with Common Terminology Criteria for Adverse Events v. 3.0. Risk factors for grade 3 to 4 ureteral stricture were analyzed. These factors included age, hydronephrosis on imaging at time of diagnosis, TNM stage, high-risk clinical target volume, laparoscopic staging, chemotherapy, radiation therapy doses to targets and organs at risk, applicator type, intracavitary versus intracavitary/interstitial technique, and dose rate. Results: At a median follow-up of 34 months (range, 2-163), 31 patients received diagnoses of grade 3 to 4 ureteral stricture. Actuarial 3- and 5-year risk for ureteral stricture grade 3 to 4 was 1.7% and 2.1%, respectively, for all patients. Advanced tumor stage T3-4 with hydronephrosis at diagnosis was the only independent risk factors for ureteral stricture (P = .01). Patients with TNM stage T1 (n = 359) had a low risk of 0.4% and 1.0% at 3 and 5 years, and those with T2 (n = 1085) had a low risk of 1.0% and 1.0% at 3 and 5 years, respectively. Patients (n = 274) with T3-T4 without hydronephrosis at diagnosis had a 3- and 5-year risk of 2.2% and 4.8%, respectively, compared with 11.5% and 11.5%, respectively, in those with baseline hydronephrosis (n = 142). Conclusions: Severe to life-threatening ureteral stricture occurs rarely in patients with locally advanced cervical cancer with T1-2 tumors. The risk for ureteral stricture is significantly increased in patients with T3-T4 tumors with hydronephrosis at diagnosis. | |
Keywords | brahiterapija radiokemoterapija rak materničnega vratu brachytherapy radiochemotherapy cervical cancer |