Author/Editor		Pižem, Jože; Boštjančič, Emanuela; Šekoranja, Daja; Pleško, Jerica; Živec, Katarina
Title		Pigmented (melanotic) myoepithelial tumor of soft tissue with EWSR1-KLF17 fusion
Type		članek
Vol. and No.		, št. Vol. 246/247
Publication year		2020
Volume		str. 48-52
ISSN		2210-7762 - Cancer genetics
Language		eng
Abstract		Myoepithelial tumors of soft tissue are rare, morphologically and biologically heterogeneous tumors. EWSR1 fusion is found in about half of the cases, followed by PLAG1 and FUS fusions. EWSR1-KLF17 fusion has so far been reported in one benign myoepithelial tumor. Using next generation sequencing we identified another myoepithelial tumor of soft tissue with EWSR1-KLF17 fusion, located on the foot in a 55-year-old male. It was composed predominantly of spindle cells with multiple small areas of epithelioid and multinucleated cells in myxohyaline stroma and areas of melanin pigment in the cytoplasm of tumor cells. The pigmented tumor cells were positive for HMB45 and, ultrastructurally, melanosomes were identified in their cytoplasm. Melanin production has not been previously documented in myoepithelial tumors of soft tissue. Our case extends the spectrum of myoepithelial tumors of soft tissue and emphasizes the importance of molecular characterization of fusions, including determination of fusion partners in myoepithelial tumors and their mimics.
Keywords		EWSR1-KLF17 fusion melanin myoepithelial tumor fuzija EWSR1-KLF17 melanin mioepitelni tumor