Author/Editor		Pirc Marolt, Tinkara; Kramar, Barbara; Bulc Rozman, Klara; Šuput, Dušan; Milisav, Irina
Title		Aripiprazole reduces liver cell division
Type		članek
Vol. and No.		Letnik 15, št. 10
Publication year		2020
Volume		str. 1-15
ISSN		1932-6203 - PloS one
Language		eng
Abstract		Effects of aripiprazole on dopamine regulation are being tested as a treatment for patients with a dual diagnosis of schizophrenia and addictions, often cocaine dependence. Aripiprazole has one of the fewest side-effects among the second-generation antipsychotics. Nevertheless, severe aripiprazole hepatotoxicity was reported in persons with a history of cocaine and alcohol abuse. Here we report that therapeutically relevant aripiprazole concentrations, equal to laboratory alert levels in patients' serum, reduce the rate of hepatocytes' division. This could be an underlying mechanism of severe liver injury development in the patients with a history of alcohol and cocaine abuse, the two hepatotoxic agents that require increased ability of liver self-regeneration. Monitoring liver functions is, therefore, important in the cases when aripiprazole is co-prescribed or used with drugs with potential hepatotoxic effects.
Keywords		aripiprazol jetra poškodbe aripiprazole liver injury