| Author/Editor | Goswami, Nandu; Taucher, Alexander Andreas; Brix, Bianca; Roessler, Andreas; Koestenberger, Martin; Reibnegger, Gilbert; Cvirn, Gerhard | |
| Title | Coagulation changes during central hypovolemia across seasons | |
| Type | članek | |
| Vol. and No. | Letnik 9, št. 11 | |
| Publication year | 2020 | |
| Volume | str. 1-12 | |
| ISSN | 2077-0383 - Journal of clinical medicine | |
| Language | eng | |
| Abstract | Lower body negative pressure (LBNP) application simulates hemorrhage. We investigated how seasons affect coagulation values at rest and during LBNP. Healthy participants were tested in cold (November-April) and warm (May-October) months. Following a 30-min supine period, LBNP was started at %10 mmHg and increased by -10 mmHg every five minutes until a maximum of - 40 mmHg. Recovery was for 10 min. Blood was collected at baseline, end of LBNP, and end of recovery. Hemostatic profiling included standard coagulation tests, calibrated automated thrombogram, thrombelastometry, impedance aggregometry, and thrombin formation markers. | |
| Keywords | seasons coagulation LBNP thrombelastometry thrombin generation trhombogram |