Author/Editor		Havrdova, E
Title		Cytokines in multiple scklerosis
Type		članek
Source		In: Vodušek DB, editor. Proceedings of the Symposium on multiple sclerosis with the 11th dr. Janez Faganel memorial lecture; 1995 Oct 6-7; Ljubljana. Ljubljana: University institute of clinical neurophysiology,
Publication year		1995
Volume		str. 16-24
Language		eng
Abstract		Cytokines are soluble polypeptide mediators controlling the growth, differentiation, and function of most cell types. They particular role as mediators of inflammation. They form a network of interactive signals, and the regulation of the preferential activation to production of stimulatory or inhibitory mediators can be decisive for the development of the disease. MS is considered to be an autoimmune disorder in which autoreactive T lymphocytes are activated in the peripheral blood, cross the blood-brain barrier, migrate to the CNS tissue to form local inflammatory lesions, and secrete numerous mediators attracting other immune cells to be engaged in myelin damage. Disease promoting cytokines, such as IFN-y, TNF-alpha, LT, IL-1 and IL-12 can be to certain extent downregulated by inhibitory cytokines such as IL-10, TGF-beta, IFN-alpha and IL-4. Increased reduction of proinflammatory cytokines can be detected by peripheral blood and/or CSF mononuclear cells of patients with exacerbation of MS, raised CSF levels of IL-2, soluble IL-2 receptors and TNF reflect activity of the disease. New therapeutic strategies according to increasing knowledge on cytokine network interacrtions are being developed, IFN-beta being a prototype of a whole new generation of biologic immunomodulators.
Descriptors		MULTIPLE SCLEROSIS CYTOKINES