| Author/Editor | Luzar, Boštjan; Falconieri, Giovanni | |
| Title | Cutaneous malignant peripheral nerve sheath tumor | |
| Type | članek | |
| Vol. and No. | Letnik 10, št. 1 | |
| Publication year | 2017 | |
| Volume | str. 337-347 | |
| ISSN | 1875-9181 - Surgical pathology clinics | |
| Language | eng | |
| Abstract | Cutaneous malignant peripheral nerve sheath tumors (MPNSTs) are rare sarcomas of neuroectodermal origin arising in the dermis and/or subcutis. In contrast with their deep soft tissue and visceral counterparts, cutaneous MPNSTs are rarely associated with neurofibromatosis type 1. Two main subtypes of cutaneous MPNST can be distinguished histologically: conventional (ie, spindle cell) and epithelioid MPNST. The 2 subtypes also differ in predilection for deep versus superficial locations, association with preexistent benign peripheral nerve sheath tumors and S100 immunohistochemistry. Herein, we review current knowledge of cutaneous MPNST and discuss its differential diagnosis. | |
| Keywords | malignant peripheral nerve sheath tumor conventional variant epithelioid variant maligni tumor ovojnice perifernega živca konvencionalna varianta epitelioidna varianta |