Author/Editor		Fouchardiere, Arnaud; Blokx, Willeke; van Kempen, Léon C; Luzar, Boštjan; Piperno-Neumann, Sophie; Puig, Susana; Alosh, Llucia; Calonje, Eduardo; Massi, Daniela
Title		ESP, EORTC, and EURACAN expert opinion
Type		članek
Publication year		2021
Volume		str. str.
ISSN		0945-6317 - Virchows Archiv : an international journal of pathology
Language		eng
Abstract		The recent WHO classification of skin tumors has underscored the importance of acknowledging intermediate grade melanocytic proliferations. A multistep acquisition of oncogenic events drives the progressive transformation of nevi into melanomas. The various pathways described are modulated by the initial oncogenic drivers that define the common, blue, and Spitz nevi groups. Intermediate lesions are most often the result of a clonal evolution within such nevi. Based on this established classification, we have suggested for each pathway a practical diagnostic approach, benefiting from the recently developed molecular tools, both in the setting of general pathology labs and expert centers. Moreover, recommendations regarding the re-excision and clinical follow-up are given to support decision-making in multidisciplinary tumor boards.
Keywords		inaktivirani nevus BAP-1 globoko prodirajoči nevus vmesni melanocitni tumorji BAP-1 inactivated nevus deep penetrating nevus intermediate melanocytic tumors