Author/Editor		Jensterle Sever, Mojca; Rizzo, Manfredi; Janež, Andrej
Title		Glucagon-like peptide 1 and taste perception
Type		članek
Vol. and No.		Letnik 22, št. 2
Publication year		2021
Volume		str. 1-13
ISSN		1422-0067 - International journal of molecular sciences
Language		eng
Abstract		Preclinical studies provided some important insights into the action of glucagon-like peptide 1 (GLP-1) in taste perception. This review examines the literature to uncover some molecular mechanisms and connections between GLP-1 and the gustatory coding. Local GLP-1 production in the taste bud cells, the expression of GLP-1 receptor on the adjacent nerves, a functional continuum in the perception of sweet chemicals from the gut to the tongue and an identification of GLP-1 induced signaling pathways in peripheral and central gustatory coding all strongly suggest that GLP-1 is involved in the taste perception, especially sweet. However, the impact of GLP-1 based therapies on gustatory coding in humans remains largely unaddressed. Based on the molecular background we encourage further exploration of the tongue as a new treatment target for GLP-1 receptor agonists in clinical studies. Given that pharmacological manipulation of gustatory coding may represent a new potential strategy against obesity and diabetes, the topic is of utmost clinical relevance.
Keywords		glukagonu podoben peptid 1 (GLP-1) okus jezik debelost sladko glucagon-like peptide 1 (GLP-1) taste tongue obesity sweet