Author/Editor		Hoehndorf, Robert; Hancock, John M.; Hardy, Nigel W.; Mallon, Ann-Marie; Schofield, Paul N.; Gkoutos, Georgios V.
Title		Analyzing gene expression data in mice with the Neuro Behavior Ontology
Type		članek
Vol. and No.		Letnik 25, št. 1/2
Publication year		2014
Volume		str. 32-40
ISSN		0938-8990 - Mammalian genome : official journal of the International Mammalian Genome Society
Language		eng
Abstract		We have applied the Neuro Behavior Ontology (NBO), an ontology for the annotation of behavioral gene functions and behavioral phenotypes, to the annotation of more than 1,000 genes in the mouse that are known to play a role in behavior. These annotations can be explored by researchers interested in genes involved in particular behaviors and used computationally to provide insights into the behavioral phenotypes resulting from differences in gene expression. We developed the OntoFUNC tool and have applied it to enrichment analyses over the NBO to provide high-level behavioral interpretations of gene expression datasets. The resulting increase in the number of gene annotations facilitates the identification of behavioral or neurologic processes by assisting the formulation of hypotheses about the relationships between gene, processes, and phenotypic manifestations resulting from behavioral observations.
Keywords		molekularna genetika ontologija nevrološki procesi molecular genetics ontology neurologic processes