Author/Editor		Meier, Samuel M.; Kreutz, Dominique; Winter, Lilli; Klose, Matthias H. M.; Cseh, Klaudia; Weiss, Tamara; Bileck, Andrea; Alte, Beatrix; Mader, Johanna C.; Wiche, Gerhard
Title		An organoruthenium anticancer agent shows unexpected target selectivity for plectin
Type		članek
Vol. and No.		Letnik 56, št. 28
Publication year		2017
Volume		str. 8267-8271
ISSN		1433-7851 - Angewandte Chemie (International ed. in English)
Language		eng
Abstract		Organometallic metal(arene) anticancer agents require ligand exchange for their anticancer activity and this is generally believed to confer low selectivity for potential cellular targets. However, using an integrated proteomics-based target-response profiling approach as a potent hypothesisgenerating procedure, we found an unexpected target selectivity of a ruthenium(arene) pyridinecarbothioamide (plecstatin) for plectin, a scaffold protein and cytolinker, which was validated in a plectin knock-out model in vitro. Plectin targeting shows potential as a strategy to inhibit tumor invasiveness as shown in cultured tumor spheroids while oral administration of plecstatin- 1 to mice reduces tumor growth more efficiently in the invasive B16 melanoma than in the CT26 colon tumor model.
Keywords		plectin anticancer agents colon plektin sredstva proti raku debelo črevo