| Author/Editor | Kačar, Mark; Fitton, John; Gough, Andrew K; Buch, Maya H; McGonagle, Dennis; Savic, Sinisa | |
| Title | Mixed results with baricitinib in biological-resistant adult-onset Still's disease and undifferentiated systemic autoinflammatory disease | |
| Type | članek | |
| Vol. and No. | Letnik 6, št. 2 | |
| Publication year | 2020 | |
| Volume | str. 1-5 | |
| ISSN | 2056-5933 - RMD open | |
| Language | eng | |
| Abstract | This clinical case series describes our experience with the use of Janus kinase 1/2 inhibitor baricitinib in two patients suffering from refractory adult-onset Still's disease (AOSD) as well as in one case suffering from AOSD-like autoinflammatory disease in the context of myelodysplastic syndrome. All patients suffered from disease nonresponsive to conventional Disease-modifying antirheumatic drugs (DMARDs) as well as biological therapies including interleukin (IL)-1 and IL-6 blockade, relying instead on high daily doses of prednisolone. We also report the first case of Pneumocystis jirovecii infection following baricitinib use. | |
| Descriptors | Still's disease, adult onset Spondylitis, ankylosing Arthritis Antirheumatic agents Stillova bolezen s pričetkom v odrasli dobi Ankilozirajoči spondilitis Artritis Antirevmatična sredstva Drug therapy Zdravljenje z zdravili | |
| Keywords | undifferentiated systemic autoinflammatory disease disease-modifying antirheumatic drugs nediferencirana sistemska avtovnetna bolezen imunomodulirajoči antirevmatiki |