| Author/Editor | Rondaij, Tadej; Rotovnik-Kozjek, Nada; Popović, Peter; Jordan, Taja | |
| Title | Vitamin D deficiency in patients with chronic intestinal failure on home parenteral nutrition | |
| Type | članek | |
| Vol. and No. | , št. Vol. 42 | |
| Publication year | 2021 | |
| Volume | str. 261 | |
| ISSN | 2405-4577 - Clinical nutrition ESPEN | |
| Language | eng | |
| Abstract | Background & aims: Vitamin D deficiency is an important complication of chronic intestinal failure (CIF). Liver steatosis is a known late complication of long-term home parenteral nutrition (HPN) therapy in patients with CIF, which can progress to intestinal failure-associated liver disease (IFALD). The aim of this study was to determine the prevalence of vitamin D deficiency among Slovene HPN patients and determine any potential correlation between serum vitamin D levels and liver steatosis associated with IFALD in adult patients with CIF on HPN therapy. Methods: Adult patients, diagnosed with CIF, receiving long term HPN therapy, were included in a cross-sectional study. Vitamin D status was determined by measuring serum levels of 25-hydroxyvitamin D. The presence of liver steatosis was diagnosed using 3 T S MRI scanner. The association between serum vitamin D levels and liver steatosis was calculated using univariate logistic regression. Results: We included 63 adult patients with CIF on HPN therapy in the study. The median duration of HPN therapy was 70 weeks. The average serum concentration of 25-hydroxyvitamin D was 41.3 nmol/l. Insufficient vitamin D levels were found in 45 (73%) patients. Liver steatosis was present in 18 (28.6%) patients. No statistically significant association between serum vitamin D levels and liver steatosis in the study population was found. Conclusion: The results of this study have shown a high prevalence of vitamin D deficiency in adult patients with CIF on HPN. We failed to demonstrate an association between serum vitamin D levels and the prevalence of liver steatosis. | |
| Keywords | vitamin D home parenteral nutrition chronic intestinal failure liver steatosis vitamin D parenteralna prehrana, domača kronična odpoved črevesja steatoza jeter |