| Author/Editor | Podlipnik, Žiga; Umek, Nejc; Kavšek, Gorazd; Blajić, Iva; Stopar Pintarič, Tatjana | |
| Title | The use of prothrombin-complex with fibrinogen concentrate for ROTEM-guided management of severe coagulopathy associated with minor placental abruption | |
| Type | članek | |
| Vol. and No. | Letnik 70, št. br. 4 | |
| Publication year | 2020 | |
| Volume | str. 371-374 | |
| ISSN | 1330-0164 - Acta medica Croatica : časopis Hrvatske akademije medicinskih znanosti | |
| Language | eng | |
| Abstract | Placental abruption can cause signifi cant hemorrhage and coagulopathy that can progress rapidly due to consumption and depletion of clotting factors. Rapid detection and treatment of hypofi brinogenemia is essential in the evolving clinical and hematologicmilieu. The use of ROTEM allows a dynamic monitoring of coagulopathy. So far, only fi brinogen concentrate has been described for prompt management of severe coagulopathy associated with placental abruption. We report a case of a 40-year-old multipara with minor placental abruption complicated by severe coagulopathy, where a combination of prothrombincomplex and fi brinogen concentrate was used for prompt treatment. Potential benefi ts and drawbacks of prothrombin complex concentrate therapy, as well as diagnostic and therapeutic considerations of ROTEM - guided test are discussed. | |
| Keywords | coagulopathy placental abruption prothrombin complex concentrate koagulopatija abrupcija posteljice koncentrat protrombinskega kompleksa |