Author/Editor		Marušič, Uroš; Pišot, Rado; Kavcic, Voyko
Title		Higher neural demands on stimulus processing after prolonged hospitalization can be mitigated by a cognitively stimulating environment
Type		članek
Vol. and No.		, št. Letn. 30
Publication year		2021
Volume		str. 55-61
ISSN		2350-5141 - Psihološka obzorja : slovenska znanstveno-strokovna psihološka revija : Horizons of psychology
Language		eng
Abstract		Prolonge d periods of complete physical inactivity or bed rest trigger various alterations in the functional and metabolic levels of the human body. However, bed rest-related adaptations of the central nervous system are less known and thoroughly studied. The aim of this study was to investigate brain electrophysiological changes using event-related potentials (ERPs) after 14 days of bed rest and 12 consecutive sessions of computerized cognitive training (CCT). Sixteen older (Mage= 60 years) healthy volunteers were randomly divided into a CCT treatment group and an active control group. All participants performed ERP measurements based on the foveal visual presentation of a circle on a black background before and after bed rest. After 14 days of bed rest, participants in the control group showed increased peak P1 amplitude (p = .012), decreased P1 latency (p = .024), and increased P2 amplitude (p = .036), while the CCT group also showed decreased P1 latency (p = .023) and decreased P2 latency (p = .049). Our results suggest that, even from a central adaptation perspective, prolonged periods of physical inactivity or bed rest trigger additional neural recruitment and should therefore be minimized, and that CCT may serve as a tool to mitigate this. Future research should focus on other aspects of central nervous system adaptation following periods of immobilization/hospitalization to improve our knowledge of infl uence of physical inactivity and its eff ects on cortical activity and to develop appropriate countermeasures to mitigate functional dysregulation.Dolgotrajna obdobja popolne gibalne neaktivnosti ali horizontalnega ležanja sprožijo v človeškem telesu različne spremembe na funkcionalni in metabolni ravni. Prilagoditve centralnega živčnega sistema, povezane s horizontalnim ležanjem, so manj poznane in še ne dovolj preučene. Namen te raziskave je bil oceniti možganske elektrofi ziološke spremembe z uporabo metode z dogodkom povezanih potencialov (ERP) po 14-dnevnem horizontalnem ležanju in 12 zaporednih vadbah računalniškega kognitivnega treninga (RKT). Šestnajst starejših (Mstarost= 60 let) zdravih prostovoljcev je bilo naključno razdeljenih v intervencijo RKT in aktivno kontrolno skupino. Vsi udeleženci so izvajali meritve ERP pred in po horizontalnem ležanju na podlagi fovealne vidne predstavitve kroga na črni podlagi. Po 14-dnevnem horizontalnem ležanju je analiza ERP pokazala povečano amplitudo P1 (p = ,012), zmanjšano latenco P1 (p = ,024) in povečano amplitudo P2 (p = ,036) pri kontrolni skupini, medtem ko sta se v skupini RKT latenci P1 (p = ,023) in P2 skrajšali (p = ,049). Naši rezultati kažejo, da daljša obdobja gibalne neaktivnosti ali horizontalnega ležanja sprožijo, tudi z vidika centralne prilagoditve, dodatno rekrutacijo nevronov, zato je treba taka obdobja zmanjšati na najmanjšo možno mero. Ugotovljeno je bilo tudi, da lahko RKT služi kot orodje za ublažitev upada. Prihodnje raziskave bi se morale osredotočiti še na druge vidike prilagajanja centralnega živčnega sistema po obdobjih imobilizacije/hospitalizacije, da bi izboljšali razumevanje posledic gibalne neaktivnosti in njenih učinkov na kortikalno aktivnost ter razvili ustrezne protiukrepe za blaženje funkcionalne disregulacije.
Keywords		staranje hospitalizacija telesna neaktivnost imobilizacija elektroencefalografija EEG računalniški kognitivni trening aging physical inactivity immobilization electroencephalography EEG computerized cognitive training