Author/Editor		Tešić, Nataša; Poženel, Primož; Švajger, Urban
Title		Overview of cellular immunotherapies within transfusion medicine for the treatment of malignant diseases
Type		članek
Vol. and No.		Letnik 22, št. 10
Publication year		2021
Volume		str. 1-19
ISSN		1422-0067 - International journal of molecular sciences
Language		eng
Abstract		Over the years, transfusion medicine has developed into a broad, multidisciplinary field that covers different clinical patient services such as apheresis technology and the development of stem cell transplantation. Recently, the discipline has found a niche in development and production of advanced therapy medicinal products (ATMPs) for immunotherapy and regenerative medicine purposes. In clinical trials, cell-based immunotherapies have shown encouraging results in the treatment of multiple cancers and autoimmune diseases. However, there are many parameters such as safety, a high level of specificity, and long-lasting efficacy that still need to be optimized to maximize the potential of cell-based immunotherapies. Thus, only a few have gained FDA approval, while the majority of them are studied in the context of investigator-initiated trials (IITs), where modern, academically oriented transfusion centers can play an important role. In this review, we summarize existing and contemporary cellular immunotherapies, which are already a part of modern transfusion medicine or are likely to become so in the future.
Keywords		transfuzijska medicina celična imunoterapija rak transfusion medicine cell-based immunotherapy cancer