Author/Editor		Mihevc, Matic; Petek Šter, Marija
Title		Vpliv pomanjkanja vitamina D3 na tveganje za okužbo s SARS-CoV-2 in potek bolezni COVID-19
Translated title		The effect of vitamin D3 deficiency on the risk of SARS-CoV-2 infection and the course of COVID-19 disease
Type		članek
Source		In: 14. mednarodna znanstvena konferenca Povezovanje zdravstvenih ved skozi teorijo in prakso za znanstveni razvoj in napredek zdravstvenih strok ter dobrobit uporabnikov : zbornik predavanj z recenzijo : 10. junij 2021 : proceedings of lectures with peer review : June 10th, 2021 Jesenice : Fakulteta za zdravstvo Angele Boškin
Publication year		2021
Volume		str. 105-113
Language		slv
Abstract		Teoretična izhodišča: Vitamin D3 (holekalciferol) je maščobotopen vitamin, ki se naravno tvori v koži in je predstopnja hormonsko aktivne oblike vitamina D (kalcitriol). Poleg pomembne vloge v uravnavanju homeostaze kalcija in fosforja, so njegovo pomanjkanje povezali s povečanim tveganjem za respiratorne okužbe. To so obrazložili z njegovim antimikrobnim, imunomodulatornim in antioksidativnim učinkom. Učinek pomanjkanja vitamina D3 v skupini pacientov okuženih s SARS-CoV-2 je slabše razjasnjen. Namen krovnega pregleda literature je pridobiti nove znanstvene dokaze za oceno vpliva pomanjkanja vitamina D3 na tveganje za okužbo s SARS-CoV-2, hud potek ali smrt zaradi bolezni COVID-19. Metoda: Januarja 2021 smo opravili krovni pregled literature v bazi PubMed. V krovni pregled smo vključili sistematične preglede literature in metaanalize, ki so ocenjevale vpliv pomanjkanja vitamina D3 na zgoraj opisane izide. Rezultati: S pomočjo iskalnega algoritma smo identificirali 13 sistematičnih pregledov, v pregled smo vključili 4. Ugotavljali smo, da so imeli pacienti serumsko vrednostjo 25-OH vitamina D <20 ng/mL (50 nmol/L) pomembno višje obete za hud potek bolezni, hospitalizacijo in smrt kot pacineti z normalnimi koncentracijami. Pomanjkanje vitamina D3 ni bilo pomembno povezano s povečanim tveganjem za okužbo s SARS-CoV-2. Razprava: Pomanjkanje vitamina D3 je pomembno povezano s težjim potekom bolezni COVID-19, višjimi obeti za hospitalizacijo in umrljivost zaradi COVID-19. Učinek preventivnega nadomeščanja vitamina D3 za preprečevanje okužbe s SARS-CoV-2 je ob trenutni ravni dokazov najverjetneje nepomembno. Potrebno so nadalje randomizirane klinične študije, ki bodo opredelile vzročno povezanost med pomanjkanjem vitamina D3 in izidi bolezni COVID-19.Theoretical background: Vitamin D3 (cholecalciferol) is a fat-soluble vitamin that is naturally formed in the skin and is a precursor to the hormonally active form of vitamin D (calcitriol). In addition to its important role in regulating calcium and phosphorus homeostasis, its deficiency has been associated with an increased risk of respiratory infections. This was explained by its antimicrobial, immunomodulatory, and antioxidant effects. The effect of vitamin D3 deficiency in the group of patients infected with SARS-CoV-2 is less well understood. The purpose of the umbrella review of the literature is to obtain new scientific evidence to assess the impact of vitamin D3 deficiency on the risk of SARS-CoV-2 infection, severe course, or death from COVID-19 disease. Methods: In January 2021, we conducted an umbrella review of the literature in the PubMed database. The umbrella review included systematic literature reviews and meta-analyses that assessed the impact of vitamin D3 deficiency on the outcomes described above. Results: Using a search algorithm, we identified 13 systematic examinations including 4. We found that patients with a serum 25-OH vitamin D value <20 ng/mL (50 nmol/L) had significantly higher prospects for severe disease. hospitalization and death as patients with normal concentrations. Vitamin D3 deficiency was not significantly associated with an increased risk of SARS-CoV-2 infection. Discussion: Vitamin D3 deficiency is significantly associated with a more severe course of COVID-19 disease, higher prospects for hospitalization, and mortality from COVID-19. The effect of preventive vitamin D3 replacement to prevent SARS-CoV-2 infection is likely to be insignificant at the current level of evidence. Further randomized clinical studies are needed to identify a causal relationship between vitamin D3 deficiency and COVID-19 disease outcome.
Keywords		vitamin D COVID-19 SARS-CoV-2 hospitalizacija ARDS umrljivost vitamin D COVID-19 SARS-CoV-2 hospitalization ARDS mortality