| Author/Editor | Gunde-Cimerman, N; Plemenitaš, A; Cimerman, A | |
| Title | A hydroxymethylglutaryl-CoA reductase inhibitor synthesized by yeasts | |
| Type | članek | |
| Source | Fems Microbiol Lett | |
| Vol. and No. | , št. 132 | |
| Publication year | 1995 | |
| Volume | str. 39-43 | |
| Language | eng | |
| Abstract | Screening of different yeast species showed that they are able to synthesize hydroxymethylglutaryl-CoA (HMGCoA) reductase inhibitors. Crude methanol extracts and the purified inhibitors from Pichia labacensis and Candida cariosilignicola were tested for their biological activity on the solubilized microsomal HMGCoA reductase from Chinese haster ovary cells. Identification of the inhibitors was studied by thin layer chromatography, high pressure liquid chromatography and mass spectroscopy. | |
| Descriptors | YEASTS ENZYME INHIBITORS HYDROXYMETHYLGLUTARYL COA REDUCTASES HAMSTERS ANIMALS, LABORATORY CHO CELLS CANDIDA SPECTRUM ANALYSIS, MASS PICHIA MICROSOMES CHROMATOGRAPHY, HIGH PRESSURE LIQUID CHROMATOGRAPHY, THIN LAYER |