Author/Editor		Žakelj-Mavrič, M
Title		The role of hydroxysteroid dehydrogenases in man and in microorganisms
Type		članek
Source		Acta Chim Slov
Vol. and No.		Letnik 42, št. 3
Publication year		1995
Volume		str. 363-71
Language		eng
Abstract		Hydroxysteroid dehydrogenases (HSD) are involved in the biosynthesis of steroid hormones in classical steroidogenic tissues. In addition, HSD are important in peripheral target tissues, where they regulate intracellular concentrations of active steroid signalling molecules. HSD can be found in microorganisms, in bacteria, and fungi. Although their role in microbial cells is not yet quite clear, our results indicate that 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) from the fungus Cochliobolus lunatus might be involved in the regulation of intracellular testosterone concentrations. The study of microbial and especially fungal HSD is promising as the results might help to elucidate the evolution of HSD and steroid hormone signalling system.
Descriptors		HYDROXYSTEROID DEHYDROGENASES STEROIDS FUNGI BACTERIA