Author/Editor		Lenart, Mitja; Simoniti, Miha; Strašek, Katja; Špik, Vesna; Selič Kurinčič, Tanja; Avšič-Županc, Tatjana
Title		Case report
Type		članek
Vol. and No.		Letnik 21, št. 1
Publication year		2021
Volume		str. 1-4
ISSN		1471-2334 - BMC infectious diseases
Language		eng
Abstract		Background: Candidatus Neoehrlichia mikurensis (CNM) is an emerging tick-born pathogen and usually causes symptomatic infection only in immunocompromised patients. Apart from one described case found in the literature where cultivation was successful, all cases so far were diagnosed by using broad-range 16S rDNA PCR. Case presentation: Our patient presented with a prolonged febrile state of unknown origin. Clinical presentation, extensive medical workup and classic microbiologic testing were non-conclusive. Several infectious agents and other causes for the febrile state were excluded. In the end, a broad-range 16S rDNA PCR was to be performed to confirm the diagnosis of CNM infection. Treatment was successful with doxycycline. Conclusions: Due to the obscurity of the pathogen, diagnostic workup in CNM is prolonged and challenging. More awareness is need about this emerging infectious disease in countries with high prevalence of tick-borne diseases as standard microbiological methods are not successful in confirming the diagnosis.
Keywords		Candidatus Neoehrlichia mikurensis infection fever of unknown origin Candidatus Neoehrlichia mikurensis okužba vročina neznanega izvora