| Author/Editor | Rodman, Jasna; Krivec, Uroš; Mrvič, Tatjana; Kogoj, Rok; Keše, Darja | |
| Title | Mycoplasma pneumoniae P1 genotype indicates severity of lower respiratory tract infections in children | |
| Type | članek | |
| Publication year | 2021 | |
| Volume | str. str. | |
| ISSN | 0095-1137 - Journal of clinical microbiology | |
| Language | eng | |
| Abstract | Background. Mycoplasma pneumoniae (M. pneumoniae) strains can be classified into two major genetic groups, P1 type 1 (P1-1) and P1 type 2 (P1-2). It remains unknown if clinical manifestations of lower respiratory tract infections (LRTI) in children differ between the two genotypes. We aimed to determine if M. pneumoniae P1 genotype is associated with severity of LRTI in children. Methods. Medical charts of 420 children (<- 15 years-old) with signs of acute LRTI who were PCR-positive for M. pneumoniae from pharyngeal swabs in a recent M. pneumoniae epidemic were analyzed. We used a culture and pyrosequencing approach for genotyping PCR-positive samples. We compared epidemiological and clinical data of children with either P1-1 or P1-2 LRTI. Results. P1-2-infected children presented with a significantly higher median baseline C-reactive protein level and were admitted to the hospital more often. P1 genotype had a significant predictive value in a multiple linear regression model predicting C-reactive protein levels in our study sample. Moreover, P1 genotype significantly affected the likelihood of hospital admission in a logistic regression model. Our modelling results were also confirmed on an additional, independent sample of children with M. pneumoniae LRTI. Conclusions. Results from our large patient group indicate that the two M. pneumoniae P1 genotypes may have different pathogenic potential and that LRTI with P1-2 strains may have a more severe disease course than those with P1-1 strains in children. P1 genotyping is not routinely performed, but could be used as a predictor of M. pneumoniae LRTI severity, enabling patient-tailored treatments. | |
| Keywords | Mycoplasma pneumoniae genetic groups genotype Mycoplasma pneumoniae genetske skupine genotip |